br NF kB is a transcription factor that is
NF-kB, is a transcription factor that is present as an inactive complex bound to its endogenous inhibitor, IkB in the cytoplasm . Phosphorylation of IkB induces its degradation and release of NF-kB from the complex, allowing NF-kB to translocate to the nucleus . Nuclear translocation of NF
Methylpiperidino pyrazole br Yi Ling Hsieha Huang Ju
Yi-Ling Hsieha,1, Huang-Ju Tua,b,1, Shiow-Lin Panc,d,e, Jing-Ping Lioub, Chia-Ron Yanga, a School of Pharmacy, College of Medicine, National Taiwan University, No. 33, Linsen S. Road, Taipei 10050, Taiwan b School of Pharmacy, College of Pharmacy, Taipei Medical University, No. 250, Wuxing
br The chronic radiation toxicity which usually
The chronic radiation toxicity, which usually presents a few months or even years after the irradiation, affects not only the parenchymal NPS-2143 in the rectum, but also the vascular endothelial cells, mainly small blood vessels and arterioles, and even fibro-blasts, leading to the formation of
br The most widely used
The most widely used approaches for flow cytometry-based phagocytosis studies involve the use of CellTracker and CFSE dyes due to their staining eﬃciency and ease of use. However, the significant deviations in data caused by cell-cell aggregation may limit the use of these conventiona
br another injection The sample injection volume was set
another injection. The sample injection volume was set at 5 mL. Mass parameters for the analysis were the following: ESI des- olvation temperature: 350 C, desolvation gas flow: 10 L min 1, capillary voltage: 4 kV, Q1 and Q3: unit resolution; nebulizer pressure: 35 psi. The Mass was operated in
br In addition clinical imaging technology is critical
In addition, clinical imaging technology is critical for observing the details of the tumor in vivo [30–32]. Among clinical imaging technol-ogies, magnetic resonance imaging (MRI) is one of the most commonly used techniques for cancer diagnosis because it can acquire high-re-solution 3D tomographic images with excellent soft-tissue contrast. Commonly, the clinical imaging process requires contrast agents (CAs) to obtain high-quality cancer images [33–38]. Currently, the clinical CAs are mainly small molecules that are passively distributed into the interstitial space of tissues and organs, making the observation of cancer tissue be diﬃcult.
br Keywords br Chemodynamic therapy br
Chemodynamic therapy (CDT) was widely exploited for cancer therapy and expected to replace traditional anticancer drug therapies. Generally, CDT needs to combine with extra therapeutic methods for obtaining the optimal therapeutic eﬃcacy of cancer. Herein, a multifunctional theranostic platform combing CDT with li-motherapy was developed via nanoselenium (nano-Se)-coated manganese carbonate-deposited iron oxide na-noparticle (MCDION-Se).